Tsunade is the grandchild of the First Hokage, Hashirama Senju, and Mito Uzumaki. Tsunades parents died when she was very young, and she was raised by her grandfather.
Tsunade is one of the most powerful ninja in the Naruto universe. She is also one of the Three Legendary Sannin, along with Jiraiya and Orochimaru. Tsunade is from the village Hidden Leaf and is a member of the Senju clan, which makes her Naruto’s great-granduncle.
Her parents were alive during the First Great Shinobi War. Her father was Hashirama Senju, who was also the First Hokage. Her mother was Mito Uzumaki, who was also the Second Hokage’s wife.
Hanaku Senju Father
Father of the Senju clan, Hanaku was a powerful figure during his time. He was known for his great strength and wisdom, which led him to be respected by many. Although he was not the original founder of the Senju clan, he is credited with helping it grow into a large and prosperous group.
Hanaku’s wife, Kaida, was also a powerful woman and together they had three sons: Hashirama, Tobirama, and Madara.

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How is Naruto Related to Tsunade?
In the world of Naruto, Tsunade is the Fifth Hokage, meaning she’s the leader of the Hidden Leaf Village. She’s also Naruto’s grandmother – which might come as a surprise to some fans, since they don’t look alike at all! So how is Tsunade related to Naruto?
Tsunade is actually Sakura’s grandmother. Sakura is Naruto’s best friend and love interest, so that makes Tsunade his grandmother by association. However, there is more to their relationship than just that.
Tsunade was once in love with Naruto’s father, Minato Namikaze. They were both young and in their prime when they fell for each other, but unfortunately Minato died before they could really pursue anything further. This hit Tsunade hard, and she withdrew from society for many years afterwards.
However, after meeting Naruto – who looks strikingly similar to Minato – Tsunade found herself slowly drawn back into the world. Seeing so much of her late lover in Naruto reignited her passion for life, and she eventually took on the role of Hokage so she could protect him (and the village) like Minato would have wanted. So while Tsunade isn’t technically related to Naruto by blood, their shared connection to Minato makes them family in every way that matters.
Who is Tsunade’S Child?
Tsunade’s child is a mystery. She has never been seen or mentioned in the series. It is possible that she does not have any children, as she never married or had any known relationships.
Was Tsunade’S Mom an Uzumaki?
There is no clear answer as to whether or not Tsunade’s mother was an Uzumaki. While it is possible that she could have been, given the close relationship between the Senju and Uzumaki clans, there is no definitive evidence to support this claim.
Who was Hashirama’S Child?
Hashirama’s child was named Madara. Madara was an incredibly powerful shinobi, and is said to have been the strongest of Hashirama’s children. Madara was also a very proactive and ambitious individual, often taking on leadership roles within the clan.
However, despite his many accomplishments, Madara always had a bit of a rebellious streak, and was known for speaking his mind – even if it meant going against Hashirama’s wishes. This eventually led to a falling out between father and son, and Madara eventually left the village.
Who Are Tsunade’s Parents?
Conclusion
Tsunade is the granddaughter of the First Hokage, Hashirama Senju, and his wife, Mito Uzumaki. She is also the niece of Tobirama Senju, the Second Hokage. Her parents died when she was very young, so she was raised by her grandfather.